Scientist - DMPK Bioanalysis

Overview:

Support in vitro ADME bioanalytical activities to generate high-quality DMPK data for drug discovery projects. Work under senior guidance to execute assays, operate LC-MS/MS systems, and develop technical expertise.

Key Responsibilities:

Operate and maintain LC-MS/MS instruments; assist with troubleshooting and data analysis.

Execute in vitro ADME assays: permeability (Caco-2/MDCK/PAMPA), metabolic stability (hepatocytes/microsomes/CYP inhibition), and physicochemical studies (solubility, Log D, stability in plasma/buffer/SGF/SIF).

Support metabolite identification (MET-ID) sample analysis and reporting.

Maintain accurate documentation, sample tracking, and project timelines.

Participate in training and mentorship to build technical proficiency.

Qualifications:

Education: M. Pharm in Pharmaceutical Analysis, Pharmaceutics, or related life science field.

Experience: 35 years in bioanalysis or DMPK/ADME, preferably in pharma/CRO.

Skills: Hands-on LC-MS/MS experience; familiarity with ADME assays, data software (e.g., Analyst, MassLynx), and GLP practices.

Attributes: Detail-oriented, strong learner, collaborative team player.