Structural Biologist

About This Job

Meril

Location: Vapi, Gujarat, India

Work Mode: On-site

Industry: Biotechnology Research

Job Description

Job Description:

• We are seeking a highly skilled and motivated Structural Biologist to join our drug
  
  

discovery programs. The ideal candidate will bring deep expertise in

macromolecular structure determination and modeling, with a focus on elucidating

protein structures, analyzing ligand binding, and driving rational drug design in

collaboration with computational and medicinal chemistry teams.

Key Responsibilities

• Analyze protein-ligand interactions to inform medicinal chemistry and lead
  
  

optimization efforts.

• Conduct molecular dynamics (MD) simulations and free energy calculations to
  
  

evaluate complex stability and binding energetics.

• Apply structural insights to guide hit-to-lead and lead optimization strategies.
• (Preferred) Utilize machine learning models to support binding site prediction or
  
  

compound prioritization.

Required Skills & Experience

• Strong expertise in structural biology techniques, such as crystallography, cryo-
  
  

EM, or NMR are desirable.

• Proficient in macromolecular modeling and structure refinement tools (e.g.,
  
  

Phenix, Coot, Chimera, PyMOL).

• Experience with protein-ligand docking, structure validation, and interaction
  
  

mapping.

• Hands-on experience with molecular dynamics simulations using tools such as
  
  

GROMACS, AMBER, NAMD, or CHARMM.

• Familiarity with structure-based drug design platforms (e.g., Schrödinger,
  
  

AutoDock).

• Scripting or programming experience (Python, R, Bash) for workflow automation and
  
  

structural data analysis.

Preferred Qualifications

• Ph.D. in Structural Biology, Biophysics, Computational Biology or related field.
• Demonstrated experience in drug discovery pipelines, especially in target
  
  

validation and lead optimization.

• (Preferred) Background in machine learning or AI applied to biomolecular structure
  
  

or ligand interaction prediction.

• Strong publication record or demonstrated project impact in therapeutic
  
  

development.

What We Offer

• Work on high-impact, discovery-stage therapeutic programs.
• Collaborative and interdisciplinary research environment.
• Access to state-of-the-art computational and structural biology platforms.