Company Description
Helex is a therapeutics company developing a new class of targeted medicines for genetic kidney diseases using its proprietary LNP drug delivery and AI-based drug design platforms. With a world-class team of scientists and drug developers, Helex operates from ASPIRE BioNEST, Hyderabad, India, and New York, USA, and is supported by Bayer Co.Lab Cambridge.
Role Description
This is a full-time on-site role located in Hyderabad, India. A Senior Scientist in Gene Editing at Helex will be responsible for leading research and development projects to advance the company's gene-editing technologies for renal applications. The day-to-day tasks will include designing and conducting experiments, analyzing data, collaborating with cross-functional teams, and staying up to date with the latest advancements in genome editing and genetic medicine.
Qualifications & Experience
- PhD in Genetics, Molecular Biology, Biotechnology, or a related field, or relevant Master's with exceptional industry experience (over 10 years)
- 3-5 years of experience with gene editing techniques such as CRISPR/Cas9 or similar technologies, in both cell and animal models
- Strong expertise in in vivo studies involving gene editing, including animal handling, dosing, and tissue analysis
- Proficiency in molecular and cellular biology assays (PCR, qPCR, ddPCR, ELISA, Western blot, flow cytometry, immunostaining).
- Experience in designing studies such as toxicology and PK/PD experiments, and executing internally and in collaboration with CROs
- Familiarity with GLP practices, IND-enabling workflows, and regulatory expectations for gene editing programs
- Excellent analytical skills, along with the ability to interpret complex data
- Ability to work collaboratively in a multi-disciplinary team environment
- Publications in peer-reviewed journals demonstrating impactful research
- Background in renal biology and kidney disease research preferred
- Experience in nanoparticle delivery systems and lipid nanoparticles is preferred, but not compulsory
