Your Responsibilities Include :
- Drive the design of medicinal chemistry efforts by applying in-depth knowledge of structure-activity relationships (SAR), a profound understanding of target biology, and predictive methods for assessing on- and off-target activity, physical properties, pharmacokinetics / pharmacodynamics (PK/PD), and synthetic feasibility.
- Thrive at the intersection of experimental and groundbreaking digital technologies, with a particular emphasis on expertise in machine learning and artificial intelligence (AI) as applied to small molecule drug discovery.
- Stay abreast of scientific literature and engage with internal and external scientists to incorporate biological insights into lead characterization and screening initiatives.
- Collaborate with interdisciplinary project teams to facilitate effective decision-making throughout the target identification to candidate nomination process. This involves applying and developing predictive models based on high-content and time-resolved screening data, including imaging techniques.
- Drive hypothesis generation to enhance clinical success rates for programs involving small molecules, peptides, RNAs, protein degradation, molecular glues, transient covalent inhibitors, and kinetic stabilization of drug-target complexes.
- Take a leading role in cross-disciplinary mechanistic studies using physics-based modeling and simulation, biophysical characterization, and cellular validation. These studies will inform the strategic targeting strategies of discovery projects, aiming for optimal mechanisms of action (MoAs).
Minimum Requirements:
- Advanced degree in medicinal chemistry, computational chemistry, computational biology, computational chemical biology, or a related field. Candidates with a laboratory-based background in chemistry and biology, supplemented with strong computational experience, are also encouraged to apply.
- 5+ years of experience working with project teams in a drug discovery environment.
- Proven track record of innovation through analogue design, leading to significant impact on discovery projects.
- Familiarity with drug design tools and high-performance computing environments and strong publication history in peer-reviewed journals.
Skills and Abilities:
- Proactively anticipates project needs with a clinical focus.
- Demonstrates rigor and diligence in idea substantiation, analogue design, and experimentation.
- Strong team orientation with multitasking and adaptability in support and leadership roles.
- Effective listener with excellent written and oral communication skills.
- Proficient in data visualization to effectively communicate insights.
