Modeling & Simulation - Senior Scientist

Company Description

InSilicoMinds specializes in advanced AI-driven modeling and simulation solutions for the Pharma and Life Sciences sectors. By collaborating with top-tier global solution providers, the company streamlines drug development processes, reduces costs, and enhances patient outcomes. InSilicoMinds leverages cutting-edge simulation tools for improving drug research and development. With a team of skilled professionals in life sciences and computational innovation, InSilicoMinds supports a diverse range of clients, from startups to multinationals, in overcoming industry-specific challenges. The company's areas of expertise include in silico modeling and simulation, bioinformatics, AI/ML, computational biology/chemistry, clinical research, and domain consultancy services.

Senior Scientist - Modeling & Simulation:

We are seeking a Senior PBPK Modeler to join our growing Modeling & Simulation team to support in silico projects across oral, modified-release, and complex drug products.

This is a hands-on scientific role focused on regulatory-grade model development, working closely with modelers and project leads to deliver high-impact in-silico evidence for drug development and regulatory decision-making.

You will play a critical role in scaling our PBPK capability and supporting multiple concurrent programs as project demand continues to grow.

Key Responsibilities

PBPK Modeling & Simulation

• Hands on experience in Develop, calibrate, and validate PBPK models for small molecules and metabolites using PK-Sim / MoBi (preferred) or equivalent platforms 

• Support oral IR, MR/ER, and complex formulations, including metabolite kinetics and accumulation risk

• Perform scenario simulations (dose, formulation, population, DDIs, food effect, steady-state exposure)

• Integrate in vitro data (solubility, permeability, dissolution, enzyme kinetics) into mechanistic models

IVIVR / IVIVC Support

• Contribute to IVIVR and IVIVC strategies linking dissolution, absorption, and systemic exposure

• Support formulation design space exploration using PBPK-led approaches

• Assist in virtual screening of formulation or release profiles where applicable

Regulatory & Scientific Deliverables

• Generate regulatory-quality reports, model descriptions, and justification documents

• Support MIDD-aligned submissions, briefing documents, and scientific responses

• Ensure modeling work meets internal quality, traceability, and documentation standards

Contribute and Learn at the Intersection of AI & Computational Modeling & Simulation

-Apply AI/ML based approaches to further bolster traditional mechanistic modeling

-Work with our AI/ML engineers to develop AI/ML tools to augment day to day modeling

Cross-Functional Collaboration

• Work closely with senior PBPK modelers, formulation scientists, and project managers

• Support internal knowledge transfer and scientific discussions

• Assist in mentoring junior team members as the group scales

Required Qualifications

• Advanced degree (MS / PhD) in Pharmaceutics, Pharmacokinetics, Pharmaceutical Sciences, Chemical Engineering, or related field

• Strong hands-on experience with PBPK modeling

• Practical experience using PK-Sim / MoBi (strongly preferred) or equivalent PBPK platforms

• Solid understanding of ADME, biopharmaceutics, and clinical pharmacokinetics

• Experience integrating in vitro, preclinical, and clinical data into mechanistic models

• Ability to independently execute modeling tasks with minimal supervision

Preferred / Nice-to-Have

• Experience with modified-release / extended-release formulations

• Exposure to IVIVC / IVIVR development

• Familiarity with regulatory expectations (FDA / EMA / ICHM15) for PBPK and MIDD

• Experience supporting regulatory submissions or scientific advice meetings

• Programming/scripting exposure (R, MATLAB, Python) is a plus but not mandatory

What We're Looking For

• Strong scientific reasoning and problem-solving skills

• Comfortable working in a fast-growing, multi-project environment

• Detail-oriented with a focus on scientific rigor and regulatory defensibility

• Collaborative mindset and willingness to support team growth

Why Join Us

• Work on high-impact PBPK and IVIVR/IVIVC programs across diverse drug products

• Exposure to regulatory-grade, real-world modeling challenges

• Opportunity to grow into technical leadership as the team scales

• Be part of a team where in-silico modeling directly drives development and regulatory decisions

Industry

• Information Technology & Services

Employment Type - Full-time