Our client, a well-funded clinical-stage biotherapeutics company developing innovative antibody therapies across oncology and autoimmunity, is seeking an experienced Clinical Pharmacology leader to support its growing pipeline. The position can be based in Singapore or Shanghai.

Reporting to a senior clinical development leader, this individual will provide strategic and operational oversight across clinical pharmacology, translational science and biomarker development.

Key responsibilities

Lead clinical pharmacology strategy across clinical-stage programs
Guide PK/PD, exposure–response, dose selection and safety-margin assessments
Evaluate the impact of immunogenicity/ADA on PK, efficacy and safety
Oversee CROs and laboratories responsible for PK/ADA modelling, assays and sample analysis
Develop biomarker strategies supporting patient selection, target engagement and pharmacodynamic assessment
Provide input into study design, clinical protocols and regulatory submissions
Collaborate across clinical development, operations, regulatory, biostatistics, bioinformatics and research

Hands-on PK/PD modelling is not required, but candidates must have sufficient technical expertise to direct external partners, assess their analyses and translate the results into clinical-development decisions.

Candidate profile

Advanced scientific or medical degree: PhD, PharmD, MD or equivalent
8+ years relevant industry experience in clinical pharmacology
Experience leading clinical pharmacology strategy and execution
Strong expertise in PK/PD, dose selection, safety margins and ADA/immunogenicity
Experience with antibodies or other biologics; exposure to ADCs, T-cell engagers or immunotherapies would be advantageous
Biomarker and translational medicine experience preferred
Experience contributing to IND, CTA, NDA/BLA submissions and health-authority interactions
Strong cross-functional leadership and communication skills

Why apply

This is a rare opportunity to join a rapidly growing, innovation-led biotherapeutics company at a pivotal stage of its development. You will play a central role in shaping an exciting biologics pipeline while working alongside an experienced executive and scientific leadership team.

Apply

If you would like to be considered for this opportunity, please click Apply or contact me directly at [HIDDEN TEXT] for a confidential discussion.

Associate Director / Director, Clinical Pharmacology & Biomarker Development